Carboxytherapy: Utilizing Carbon Dioxide for Enhancing Skin Health

The Carboxytherapy skincare regimen  technique involves the direct infusion of CO2 into the skin, which rapidly spreads within the skin and muscle microcirculation. This action boosts tissue oxygen levels and promotes new blood vessel formation. As a result, blood vessels expand, enhancing oxygen transport to body tissues, aiding in cell renewal, and reducing inflammation.

Originating in the 1930s, carboxytherapy has evolved, particularly in its delivery methods. The modern approach includes a gel-based system, CO2Lift®.

The process leverages carbon dioxide to enhance blood and lymph flow to the targeted area, thereby improving circulation, skin elasticity, and diminishing fine lines and wrinkles. Traditionally, carboxytherapy involved injecting CO2 under the skin using a fine, high-gauge needle. This method causes minimal pain and discomfort, with only slight bruising as a side effect.

Presently, Topical Carboxytherapy: A Non-Invasive Carbon Dioxide Infusion Approach

The latest advancement in carboxytherapy eliminates the need for injections. CO2Lift® Carboxytherapy is an innovative development designed to utilize the body’s innate reaction to carbon dioxide effectively. This method provides the advantages of carbon dioxide therapy through a non-invasive topical application.

Carboxytherapy 's Skincare Regimen Multifaceted Benefits for Skin Rejuvenation:

  • Enhances wound healing factors and growth factors, accelerating cellular renewal. This diminishes signs of aging, scars, stretch marks, and similar concerns.
  • Boosts collagen and elastin synthesis, fostering skin elasticity and moisture retention.
  • Optimizes local metabolism and aids in waste removal, facilitating the healing of specific skin issues like scars or acne-related hyperpigmentation.
  • Aids in the regeneration and repair of damaged tissues, leading to healthier and more aesthetically pleasing skin.

What is CO2Lift® Carboxytherapy Gel?

  • Introduced in 2015, CO2Lift® Carboxytherapy Gel is a convenient at-home skincare regimen that efficiently utilizes treatment time, offering results comparable to injection therapies.* It’s a versatile solution suitable for various professionals, including surgeons, aesthetic and medical practitioners, and aestheticians.
  • This potent anti-aging and cosmetic product is designed for use on the face, eyes, body, and vaginal area. It aids in rejuvenating vulva/vaginal tissues, mitigating symptoms of Genitourinary Syndrome of Menopause (GSM).*** Additionally, it has shown effectiveness in healing diabetic ulcers within just four treatments.****

  • CO2Lift® focuses on addressing individual aging skin concerns without relying on machines, harsh peels, injections, or cosmetic surgery.


* Leibascoff, G, Roberts W, Coll L, 2018 Surgical Tech Int
** Biometrrix 2017 Hydration Study
*** Leibaschoff G, Reyes C, Arrieta C, Melamed J, 2021 Surgical Tech Int.
**** Pilot study conducted by Dr. Laura Slack


Carboxytherapy Skincare Regimen Effects

  • Vasodilation: Enhances blood vessel expansion.*
  • Augmented Flow Motion: Boosts fluid dynamics within tissues.*
  • Growth Factor Elevation: Notably increases factors like VEGF, aiding in cellular growth and development.
  • Microcirculation Enhancement: Improves the flow of blood through small vessels.
  • Neoangiogenesis Stimulation: Encourages the formation of new blood vessels.
  • Elevated Tissue Oxygenation: Increases oxygen levels in tissues, leveraging the Bohr Effect.**
  • Neoprocollagenesis: Stimulates the production of new collagen.
  • pH Correction: Balances the pH levels within tissues.
  • ECM (Extracellular Matrix) Cleansing: Enhances tissue health by removing impurities.***
  • Connective Tissue Biostimulation: Invigorates the connective tissue for better function.****
  • Restoration of Microvascular-Tissular Exchanges: Improves the interaction between small blood vessels and tissues.*****



* Hartmann BR, Bassenge E Angiology 48:337, 1997 • Abramo AC Rev Bras Cir Plast, 2009 • Varlaro V Blood 2007
** Vacher, 1987
*** Maia-Figueiró TL, ODashire AN, Menezes GP
**** Ferreira JCT J Drugs Dermatol, 2008
***** Curri, Albergati, 1997

Patients not only see enhanced healing from their primary burns but also observe substantial improvements in their skin’s appearance.

These improvements encompass:

  • Diminished fine lines
  • Smoother wrinkles
  • Minimized pores
  • Tighter, firmer skin texture

The outcomes were undeniable—the use of cutaneous carboxytherapy gel holds significant promise for anti-aging skincare applications.

Mechanism of Action

The surge in oxygen levels is crucial for generating the energy required for cell division and activation.

Detailed illustration of Carboxytherapy Skin Treatment procedure steps.
Before and after photos showing the effectiveness of Carboxytherapy Skin Treatment.
Patient undergoing Carboxytherapy Skin Treatment at a clinic.


When the skin absorbs CO2, it creates an oxygen shortage in the underlying tissues, prompting the body to increase oxygen delivery to the affected area.


The influx of extra oxygen through the blood leads to the expansion of blood vessels in the area.


The blood, enriched with oxygen, delivers essential nutrients and substances that regulate immune responses to the cells.

How Is the CO2 Created?

Upon combining the water from the larger packet with the small packet’s gluconolactone, a gentle acid is formed. This mild acid then reacts with magnesium carbonate to produce CO2. The CO2 generated from this reaction is then gently and hypoallergically absorbed into the skin, making it a distinctive and mild skincare regimen method.

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